@article {13,
	title = {Genomic organization of human and mouse genes for vascular endothelial growth factor C},
	journal = {J Biol Chem},
	volume = {272},
	year = {1997},
	month = {1997/Oct/},
	pages = {25176 - 83},
	abstract = {We report here the cloning and characterization of human and mouse genes for vascular endothelial growth factor C (VEGF-C), a newly isolated member of the vascular endothelial growth factor/platelet-derived growth factor (VEGF/PDGF) family. Both VEGF-C genes comprise over 40 kilobase pairs of genomic DNA and consist of seven exons, all containing coding sequences. The VEGF homology domain of VEGF-C is encoded by exons 3 and 4. Exons 5 and 7 encode cysteine-rich motifs of the type C6C10CRC, and exon 6 encodes additional C10CXCXC motifs typical of a silk protein. A putative alternatively spliced rare RNA form lacking exon 4 was identified in human fibrosarcoma cells, and a major transcription start site was located in the human VEGF-C gene 523 base pairs upstream of the translation initiation codon. The upstream promoter sequences contain conserved putative binding sites for Sp-1, AP-2, and NF-kappaB transcription factors but no TATA box, and they show promoter activity when transfected into cells. The VEGF-C gene structure is thus assembled from exons encoding propeptides and distinct cysteine-rich domains in addition to the VEGF homology domain, and it shows both similarities and distinct differences in comparison with other members of the VEGF/PDGF gene family.},
	url = {http://view.ncbi.nlm.nih.gov/pubmed/9312130},
	author = {Chilov, D and Kukk, E and Taira, S and Jeltsch, M and Kaukonen, J and Palotie, A and Joukov, V and Alitalo, K}
}
