@article {858,
	title = {The relationship between the secondary vascular system and the lymphatic vascular system in fish},
	journal = {Biological Reviews},
	year = {2024},
	month = {Apr-06-2026},
	issn = {1464-7931},
	doi = {10.1111/brv.13114},
	url = {https://onlinelibrary.wiley.com/doi/10.1111/brv.13114},
	author = {Panara, Virginia and Varaliov{\'a}, Zuzana and Wilting, J{\"o}rg and Koltowska, Katarzyna and Jeltsch, Michael}
}
@inbook {500,
	title = {The genetic causes of primary lymphedema.},
	booktitle = {Erkrankungen des Lymphgef{\"a}{\ss}systems},
	year = {2015},
	pages = {210-229},
	publisher = {Viavital Verlag},
	organization = {Viavital Verlag},
	edition = {6},
	chapter = {5},
	address = {Cologne},
	abstract = {English:
Primary lymphedema can be treated, but not cured. In addition, their diagnosis is due to heterogeneous phenotypes often ambiguous. However, these problems can be tackled by identifying the edema-causing genetic lesions to yield unambiguous diagnoses and by developing specific treatments that address the underlying, molecular cause. New developments in molecular biology are providing the necessary tools for these tasks and in the recent years the genetic causes of many forms of primary lymphedema have been identified, notably by exome sequencing. For a significant proportion of lymphatic disorders multifactorial genetic causes are suspected.
This chapter provides an overview of the current knowledge on the genetic origin, the categorization as well as the molecular and biochemical causes of primary lymphedema.

German:
Prim{\"a}re Lymph{\"o}deme sind behandelbar, aber nicht heilbar. Zudem ist die Diagnostik aufgrund heterogener Ph{\"a}notypen oft nicht eindeutig. Um diese Probleme anzugehen, m{\"u}ssen die das {\"O}dem verursachenden genetischen Ursachen gefunden, diagnostiziert und gezielt behandelt werden. Die hierzu notwendigen Techniken liefern die neuen Entwicklungen in der Molekularbiologie. Insbesondere durch die Technik der Exom-Sequenzierung wurden in den letzten Jahren die genetischen Ursachen vieler prim{\"a}rer Lymph{\"o}deme identifiziert. F{\"u}r einen weiteren gro{\ss}en Anteil dieser Erkrankungen werden multifaktorielle genetische Dispositionen vermutet.
Dieses Kapitel gibt einen {\"U}berblick {\"u}ber den derzeitigen Kenntnisstand der genetischen Ursachen, der Kategorisierung sowie der molekularbiologischen und biochemischen Grundlagen prim{\"a}rer Lymph{\"o}deme.},
	isbn = {978-3-934371-53-8},
	author = {Mattonet, Kenny and Wilting, J{\"o}rg and Jeltsch, Michael},
	editor = {Weissleder, Horst and Schuchhardt, Christian}
}
@article {25,
	title = {Genesis and pathogenesis of lymphatic vessels},
	journal = {Cell Tissue Res},
	volume = {314},
	year = {2003},
	month = {2003/Oct/},
	pages = {69 - 84},
	abstract = {The lymphatic system is generally regarded as supplementary to the blood vascular system, in that it transports interstitial fluid, macromolecules, and immune cells back into the blood. However, in insects, the open hemolymphatic (or lymphohematic) system ensures the circulation of immune cells and interstitial fluid through the body. The Drosophila homolog of the mammalian vascular endothelial growth factor receptor (VEGFR) gene family is expressed in hemocytes, suggesting a close relationship to the endothelium that develops later in phylogeny. Lymph hearts are typical organs for the propulsion of lymph in lower vertebrates and are still transiently present in birds. The lymphatic endothelial marker VEGFR-3 is transiently expressed in embryonic blood vessels and is crucial for their development. We therefore regard the question of whether the blood vascular system or the lymphatic system is primary or secondary as open. Future molecular comparisons should be performed without any bias based on the current prevalence of the blood vascular system over the lymphatic system. Here, we give an overview of the structure, function, and development of the lymphatics, with special emphasis on the recently discovered lymphangiogenic growth factors.},
	url = {http://view.ncbi.nlm.nih.gov/pubmed/12942362},
	author = {Jeltsch, Michael and Tammela, Tuomas and Alitalo, Kari and Wilting, J{\"o}rg}
}
