01315nas a2200121   4500008004100000020001600041245005100057210005000108260000900158490000600167520096300173856005701136       2013                        eng d  a, 1943-026400aReceptor Tyrosine Kinase-Mediated Angiogenesis0 aReceptor Tyrosine KinaseMediated Angiogenesis  c20130 v53 aThe endothelial cell is the essential cell type forming the inner layer of the vasculature. Two families of receptor tyrosine kinases (RTKs) are almost completely endothelial cell specific: the vascular endothelial growth factor (VEGF) receptors (VEGFR1-3) and the Tie receptors (Tie1 and Tie2). Both are key players governing the generation of blood and lymphatic vessels during embryonic development. Because the growth of new blood and lymphatic vessels (or the lack thereof) is a central element in many diseases, the VEGF and the Tie receptors provide attractive therapeutic targets in various diseases. Indeed, several drugs directed to these RTK signaling pathways are already on the market, whereas many are in clinical trials. Here we review the VEGFR and Tie families, their involvement in developmental and pathological angiogenesis, and the different possibilities for targeting them to either block or enhance angiogenesis and lymphangiogenesis.  uhttp://cshperspectives.cshlp.org/content/5/9/a009183