02115nas a2200133   4500008004100000020001300041245007300054210006900127260001600196300001200212490000800224520168300232856006601915       2018                        eng d  a0940960200aKey molecules in lymphatic development, function, and identification0 aKey molecules in lymphatic development function and identificati  c2018/09/01/  a25 - 340 v2193 aWhile both blood and lymphatic vessels transport fluids and thus share many similarities, they also show functional and structural differences, which can be used to differentiate them. Specific visualization of lymphatic vessels has historically been and still is a pivot point in lymphatic research. Many of the proteins that are investigated by molecular biologists in lymphatic research have been defined as marker molecules, i.e. to visualize and distinguish lymphatic endothelial cells (LECs) from other cell types, most notably from blood vascular endothelial cells (BECs) and cells of the hematopoietic lineage.Among the factors that drive the developmental differentiation of lymphatic structures from venous endothelium, Prospero homeobox protein 1 (PROX1) is the master transcriptional regulator. PROX1 maintains lymphatic identity also in the adult organism and thus is a universal LEC marker. Vascular endothelial growth factor receptor-3 (VEGFR-3) is the major tyrosine kinase receptor that drives LEC proliferation and migration. The major activator for VEGFR-3 is vascular endothelial growth factor-C (VEGF-C). However, before VEGF-C can signal, it needs to be proteolytically activated by an extracellular protein complex comprised of Collagen and calcium binding EGF domains 1 (CCBE1) protein and the protease A disintegrin and metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3).This minireview attempts to give an overview of these and a few other central proteins that scientific inquiry has linked specifically to the lymphatic vasculature. It is limited in scope to a brief description of their main functions, properties and developmental roles.  uhttp://linkinghub.elsevier.com/retrieve/pii/S094096021830071200451nas a2200109   4500008004100000245014500041210006900186260001600255300000900271490000600280856005500286       2017                        eng d00aEfficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE10 aEfficient activation of the lymphangiogenic growth factor VEGFC   c2017/07/07/  a49160 v7  uhttps://www.nature.com/articles/s41598-017-04982-1