01640nas a2200133   4500008004100000022001300041245009100054210006900145260001600214300001700230490000700247520118000254856007201434       2025                        eng d  a1934590900aFetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin0 aFetallike reversion in the regenerating intestine is regulated b  cJan-04-2025  a613 - 626.e80 v323 aMesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in epithelial conversion into a fetal-like regenerative state after damage is not known. We modeled epithelial regeneration by culturing intestinal epithelium on decellularized small intestinal scaffolds (iECM) and identify asporin (Aspn), an ECM-bound proteoglycan, as a critical mediator of epithelial fetal-like reprogramming. After damage, transient increase in Aspn expression by the pericryptal fibroblasts induces epithelial transforming growth factor b (TGF-b)-signaling via CD44 and promotes timely epithelial reprogramming. Temporal control of Aspn is lost in old mice, and after damage, the persistently high level of Aspn stagnates epithelium in the regenerative state. Increase in Wnt signaling can resolve the stagnated regenerative program of the old epithelium, promoting restoration of tissue function. In summary, we establish a platform for modeling epithelial injury responses ex vivo and show that the mesenchymal Aspn-producing niche modulates tissue repair by regulating epithelial fetal-like reprogramming.  uhttps://www.sciencedirect.com/science/article/pii/S193459092500048700463nas a2200121   4500008004100000022001400041245012000055210007100175260001600246300001000262490000700272856006200279       2020                        eng d  a2324-926900aInvestigation on the role of biallelic variants in VEGF‐C found in a patient affected by Milroy‐like lymphedema0 aInvestigation on the role of biallelic variants in VEGF‐C found   cFeb-06-2022  ae13890 v00  uhttps://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.1389