Mavali-Zadeh A, Gatto E, Lettieri R, Bokharaie B, Caravella A, D'Ottavi C, et al.. Biomass-derived Lignin Nanoparticles for the Sustained Delivery of Vascular Endothelial Growth Factor-C. Molecular Pharmaceutics [Internet]. Submitted;. https://doi.org/10.1101/2025.04.23.649697

Iqbal S, Andersson S, Nesta E, Pentinmikko N, Kumar A, Jha SK, et al.. Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin. Cell Stem Cell [Internet]. 2025;32(4):613 - 626.e8. https://www.sciencedirect.com/science/article/pii/S1934590925000487

Reunanen S, Ghemtio L, Patel JZ, Patel DR, Airavaara K, Yli-Kauhaluoma J, et al.. Targeting Bacterial and Human Levodopa Decarboxylases for Improved Drug Treatment of Parkinson's Disease: Discovery and Characterization of New Inhibitors. European Journal of Pharmaceutical Sciences [Internet]. 2025;:107133. https://authors.elsevier.com/sd/article/S0928-0987(25)00132-0

Niemelä A, Giorgi L, Nouri S, Yurtta? B, Rauniyar K, Jeltsch M, et al.. Gliflozins, sucrose and flavonoids are allosteric activators of lecithin-cholesterol acyltransferase. Scientific Reports [Internet]. 2024;14(1):26085. https://www.nature.com/articles/s41598-024-77104-3

Panara V, Varaliová Z, Wilting J, Koltowska K, Jeltsch M. The relationship between the secondary vascular system and the lymphatic vascular system in fish. Biological Reviews [Internet]. 2024;. https://onlinelibrary.wiley.com/doi/10.1111/brv.13114

López-Cerdá S, Molinaro G, ParejaTello R, Correia A, Künig S, Steinberger P, et al.. Study of the Synergistic Immunomodulatory and Antifibrotic Effects of Dual-Loaded Budesonide and Serpine1 siRNA Lipid?Polymer Nanoparticles Targeting Macrophage Dysregulation in Tendinopathy. ACS Applied Materials & Interfaces [Internet]. 2024;16(15):18643 - 18657. https://pubs.acs.org/doi/10.1021/acsami.4c02363

Rauniyar K, Bokharaie H, Jeltsch M. Expansion and collapse of VEGF diversity in major clades of the animal kingdom. Angiogenesis [Internet]. 2023;26(3):437 - 461. https://link.springer.com/10.1007/s10456-023-09874-9

Rauniyar K, Akhondzadeh S, G?ciarz A, Künnapuu J, Jeltsch M. Bioactive VEGF-C from E. coli. Scientific Reports [Internet]. 2022;12(1). https://www.nature.com/articles/s41598-022-22960-0

Jeltsch M, Alitalo K. Lymphatic-to-blood vessel transdifferentiation in zebrafish. Nature Cardiovascular Research [Internet]. 2022;1(6):539 - 541. https://rdcu.be/cOjJ0

Jeltsch M. Drug-induced lymphangiogenesis. In 3. Schweizer Lymphsymposium [Internet]. Juzo; 2021. https://doi.org/10.5281/zenodo.6034307

Koistinen H, Künnapuu J, Jeltsch M. KLK3 in the Regulation of Angiogenesis?Tumorigenic or Not?. International Journal of Molecular Sciences [Internet]. 2021;22(24):13545. https://www.mdpi.com/1422-0067/22/24/13545

Künnapuu J, Jeltsch M. Outside in and brakes off for lymphatic growth. Science Signaling [Internet]. 2021;14(695). https://www.science.org/doi/10.1126/scisignal.abj5058

Künnapuu J, Bokharaie H, Jeltsch M. Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs. Biology [Internet]. 2021;10(2):167. https://www.mdpi.com/2079-7737/10/2/167

Mukenge S, Jha SK, Catena M, Manara E, Leppänen V?M, Lenti E, et al.. Investigation on the role of biallelic variants in VEGF?C found in a patient affected by Milroy?like lymphedema. Molecular Genetics & Genomic Medicine [Internet]. 2020;00:e1389. https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.1389

Gucciardo E, Lehti TA, Korhonen A, Salvén P, Lehti K, Jeltsch M, et al.. Lymphatics and the eye. [Finnish]. Duodecim Lääketieteellinen Aikakauskirja [Internet]. 2020;136(16):1777-1788. https://www.duodecimlehti.fi/lehti/2020/16/duo15739

Fang S, Chen S, Nurmi H, Leppänen V-M, Jeltsch M, Scadden DT, et al.. VEGF-C Protects the Integrity of Bone Marrow Perivascular Niche. Blood [Internet]. 2020;:accepted - for publication. https://ashpublications.org/blood/article/doi/10.1182/blood.2020005699/463465/VEGF-C-Protects-the-Integrity-of-Bone-Marrow

Jha SK, Rauniyar K, Chronowska E, Mattonet K, Maina EW, Koistinen H, et al.. KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D. eLife [Internet]. 2019;8:e44478. https://elifesciences.org/articles/44478

Lackner M, Schmotz C, Jeltsch M. The Proteolytic Activation of Vascular Endothelial Growth Factor-C. Lymphologie in Forschung und Praxis [Internet]. 2019;23(2):88 - 98. https://doi.org/10.5281/zenodo.3629263

Jha SK, Rauniyar K, Kärpänen T, Leppänen V-M, Brouillard P, Vikkula M, et al.. Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1. Scientific Reports [Internet]. 2017;7(1):4916. https://www.nature.com/articles/s41598-017-04982-1

Jeltsch M. What you should know about VEGF-C when working with lymphatics [German]. In Lymphologie 2017 [Internet]. Bad Soden (Frankfurt), Germany; 2017. https://jeltsch.org/Abstrakt-BadSoden2017

Batchu KC, Hänninen S, Jha SK, Jeltsch M, Somerharju P. Factors regulating the substrate specificity of cytosolic phospholipase A2-alpha in vitro. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2016;1861(11):1597. 

Jeltsch M. From Molecular Genetics and Biology to Effective Treatments of Lymphatic Disorders [Internet]. 42nd  Congress of the European Society of Lymphology. Mulhouse, France; 2016. http://www.eurolymphology.org/JOURNAL/VOL28-N74-2016/#p=14

Johns SC, Yin X, Jeltsch M, Bishop JR, Schuksz M, Ghazal REl, et al.. Functional Importance of a Proteoglycan Co-Receptor in Pathologic Lymphangiogenesis. Circulation Research [Internet]. 2016;119(2):210-221. http://circres.ahajournals.org/content/early/2016/05/25/CIRCRESAHA.116.308504

Schaupper MV, Jeltsch M, Rohringer S, Redl H, Holnthoner W. Lymphatic Vessels in Regenerative Medicine and Tissue Engineering. Tissue Engineering Part B [Internet]. 2016;22(5):1-13. http://online.liebertpub.com/doi/10.1089/ten.TEB.2016.0034

M Roukens G, Peterson-Maduro J, Padberg Y, Jeltsch M, Leppänen V-M, Bos FL, et al.. Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain. Circ Res [Internet]. 2015;116(10):1660-1669. http://circres.ahajournals.org/content/116/10/1660.long

Mattonet K, Wilting J, Jeltsch M. The genetic causes of primary lymphedema. In: Weissleder H, Schuchhardt C. Erkrankungen des Lymphgefäßsystems. 6th ed. Cologne: Viavital Verlag; 2015. pp. 210-229. 

Mattonet K, Jeltsch M. Heterogeneity of the origin of the lymphatic system. [German]. Lymphologie in Forschung und Praxis [Internet]. 2015;19(2):84-88. http://www.dglymph.de/fileadmin/global/pdfs/LymphForsch_2-15.pdf

Jeltsch M. Lymphangiogenesis in Health and Disease [Internet]. 41st European Societry of Lymphology (ESL) Congress. Lausanne, Switzerland: European Group of Lymphology; 2015. http://www.eurolymphology.org/JOURNAL/VOL26-N72-2015/#p=10

Batchu KChaithanya, Hokynar K, Jeltsch M, Mattonet K, Somerharju P. Substrate efflux propensity is the key determinant of iPLA-?-mediated glycerophospholipid hydrolysised. Journal of Biological Chemistry [Internet]. 2015;. http://www.jbc.org/content/early/2015/02/23/jbc.M115.642835.abstract

Saharinen P, Jeltsch M, Santoyo MM, Leppänen V-M, Alitalo K. The TIE Receptor Family. In: Wheeler DL, Yarden Y. Receptor Tyrosine Kinases: Family and Subfamilies [Internet]. Springer International Publishing; 2015. pp. 743-775. https://link.springer.com/content/pdf/10.1007%2F978-3-319-11888-8_16.pdf

Jeltsch M, Jha SKumar, Tvorogov D, Anisimov A, Leppänen V-M, Holopainen T, et al.. CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated VEGF-C activation. Circulation [Internet]. 2014;129(19). http://circ.ahajournals.org/content/early/2014/02/19/CIRCULATIONAHA.113.002779.abstract

Anisimov A, Leppänen V-M, Tvorogov D, Zarkada G, Jeltsch M, Holopainen T, et al.. The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands. Sci Signal. 2013;6(282):ra52. 

Die lymphangiogenen Wachstumsfaktoren VEGF-C und VEGF-D. Lymphologie in Forschung und Praxis. 2013;17(1):30-37. 

Krebs R, Jeltsch M. Die lymphangiogenic growth factors VEGF-C and VEGF-D. Part 2: The role of VEGF-C and VEGF-D in diseases of the lymphatic system. [bilingual: English, German]. Lymphologie in Forschung und Praxis [Internet]. 2013;17(2):96 - 104. http://jeltsch.org/sites/jeltsch.org/files/JeltschMichael_Lymphforsch2013_96.pdf

Krebs R, Jeltsch M. The lymphangiogenic growth factors VEGF-C and VEGF-D. Part 1: Basic principles and embryonic development. [bilingual: English, German]. Lymphologie in Forschung und Praxis [Internet]. 2013;17(1):30 - 37. http://jeltsch.org/sites/jeltsch.org/files/JeltschMichael_Lymphforsch2013_30.pdf

Jeltsch M, Leppänen V-M, Saharinen P, Alitalo K. Receptor Tyrosine Kinase-Mediated Angiogenesis. Cold Spring Harbor Perspectives in Biology [Internet]. 2013;5(9). http://cshperspectives.cshlp.org/content/5/9/a009183

Leppänen V-M, Tvorogov D, Kisko K, Prota AE, Jeltsch M, Anisimov A, et al.. Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2013;110(32):12960 - 12965. http://www.pnas.org/content/110/32/12960.long

Villefranc JA, Nicoli S, Bentley K, Jeltsch M, Zarkada G, Moore JC, et al.. A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development. 2013;140(7):1497-506. 

Krebs R, Tikkanen JM, Ropponen JO, Jeltsch M, Jokinen JJ, Ylä-Herttuala S, et al.. Critical role of VEGF-C/VEGFR-3 signaling in innate and adaptive immune responses in experimental obliterative bronchiolitis. Am J Pathol. 2012;181(5):1607-20. 

Leppänen V-M, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, et al.. Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. Blood [Internet]. 2011;117(5):1507 - 15. http://view.ncbi.nlm.nih.gov/pubmed/21148085

Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, et al.. Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development. Genes Dev [Internet]. 2010;24(9):875 - 80. http://view.ncbi.nlm.nih.gov/pubmed/20439428

Tvorogov D, Anisimov A, Zheng W, Leppänen V-M, Tammela T, Laurinavicius S, et al.. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell [Internet]. 2010;18(6):630 - 40. http://view.ncbi.nlm.nih.gov/pubmed/21130043

Leppänen V-M, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, et al.. Structural determinants of growth factor binding and specificity by VEGF receptor 2. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2010;107(6):2425 - 30. http://view.ncbi.nlm.nih.gov/pubmed/20145116

Albrecht I, Kopfstein L, Strittmatter K, Schomber T, Falkevall A, Hagberg CE, et al.. Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis. PLoS ONE [Internet]. 2010;5(11):e14109. http://view.ncbi.nlm.nih.gov/pubmed/21124841

Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J, et al.. Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation. Circulation [Internet]. 2010;122(17):1725 - 33. http://view.ncbi.nlm.nih.gov/pubmed/20937974

Anisimov A, Alitalo A, Korpisalo P, Soronen J, Kaijalainen S, Leppänen V-M, et al.. Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle. Circ Res [Internet]. 2009;104(11):1302 - 12. http://view.ncbi.nlm.nih.gov/pubmed/19443835

Karpanen T, Bry M, Ollila HM, Seppänen-Laakso T, Liimatta E, Leskinen H, et al.. Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Circ Res [Internet]. 2008;103(9):1018 - 26. http://view.ncbi.nlm.nih.gov/pubmed/18757827

Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, et al.. Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arterioscler Thromb Vasc Biol [Internet]. 2008;28(9):1614 - 20. http://view.ncbi.nlm.nih.gov/pubmed/18511699

Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Ylä-Herttuala S, et al.. The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. Cancer Res [Internet]. 2008;68(12):4754 - 62. http://view.ncbi.nlm.nih.gov/pubmed/18559522

Tammela T, He Y, Lyytikkä J, Jeltsch M, Markkanen J, Pajusola K, et al.. Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins. Circ Res [Internet]. 2007;100(10):1468 - 75. http://view.ncbi.nlm.nih.gov/pubmed/17478733

Keskitalo S, Tammela T, Lyytikka J, Karpanen T, Jeltsch M, Markkanen J, et al.. Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein. Circ Res [Internet]. 2007;100(10):1460 - 7. http://view.ncbi.nlm.nih.gov/pubmed/17478734

Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Wedge SR, et al.. Inhibiton of VEGF-C-induced VEGFR-3 activity and lymphatic endothelial cell function by the tyrosine kinase inhibitor AZD2171. In 98th Annual Meeting of the American-Association-for-Cancer-Research [Internet]. Los Angeles, CA: American Association for Cancer Research; 2007. http://dx.doi.org/10.1158/0008-5472.CAN-07-5809

Kärpänen T, Heckman CA, Keskitalo S, Jeltsch M, Ollila H, Neufeld G, et al.. Functional interaction of VEGF-C and VEGF-D with neuropilin receptors. FASEB J [Internet]. 2006;20(9):1462 - 72. http://view.ncbi.nlm.nih.gov/pubmed/16816121

Jeltsch M, Karpanen T, Strandin T, Aho K, Lankinen H, Alitalo K. Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns. J Biol Chem [Internet]. 2006;281(17):12187 - 95. http://view.ncbi.nlm.nih.gov/pubmed/16505489

Jeltsch M, Alitalo K. VEGF Receptors. In Sigma-RBI Handbook of Receptor Classification and Signal Transduction [Internet]. 5.th ed. Sigma; 2006. http://www.sigmaaldrich.com/technical-documents/articles/biology/rbi-handbook.html

Baluk P, Tammela T, Ator E, Lyubynska N, Achen MG, Hicklin DJ, et al.. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest [Internet]. 2005;115(2):247 - 57. http://view.ncbi.nlm.nih.gov/pubmed/15668734

He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, et al.. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res [Internet]. 2005;65(11):4739 - 46. http://view.ncbi.nlm.nih.gov/pubmed/15930292

Karkkainen MJ, Haiko P, Sainio K, Partanen J, Taipale J, Petrova TV, et al.. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol [Internet]. 2004;5(1):74 - 80. http://view.ncbi.nlm.nih.gov/pubmed/14634646

Jeltsch M, Tammela T, Alitalo K, Wilting J. Genesis and pathogenesis of lymphatic vessels. Cell Tissue Res [Internet]. 2003;314(1):69 - 84. http://view.ncbi.nlm.nih.gov/pubmed/12942362

Veikkola T, Lohela M, Ikenberg K, Mäkinen T, Korff T, Saaristo A, et al.. Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function. FASEB J [Internet]. 2003;17(14):2006 - 13. http://view.ncbi.nlm.nih.gov/pubmed/14597670

Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, et al.. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol [Internet]. 2003;161(6):1163 - 77. http://view.ncbi.nlm.nih.gov/pubmed/12810700

Saaristo A, Veikkola T, Enholm B, Hytönen M, Arola J, Pajusola K, et al.. Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes. FASEB J [Internet]. 2002;16(9):1041 - 9. http://view.ncbi.nlm.nih.gov/pubmed/12087065

Jeltsch M. VEGFR-3 Ligands and Lymphangiogenesis [Internet]. University of Helsinki. 2002. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/jeltsch

Jeltsch M. Functional Analysis of VEGF-B and VEGF-C [Internet]. University of Helsinki. [Helsinki]: Univeristy of Helsinki; 1997. http://urn.fi/URN:NBN:fi-fe977347